The Afro-Cuban religion of Santeria is the product of the encounter between Yoruba Orisha worship and Spanish Catholicism in Cuba. Enslaved Africans hid their beliefs and customs with those imposed by the Spanish colonists.

From the 16th century through the 19th century, close to one million Africans from West and Central Africa were captured and transported to Cuba. The trade in African people increased during the late 18th and 19th centuries, with the growth of the island’s plantations. During this period, the Yoruba (from what is now southwestern Nigeria and eastern Benin) were one of the principal ethnic groups to be brought to the island. In Cuba the Yoruba, or Lukumí, had a major cultural influence on the Africans of various ethnic backgrounds.

The Orishas are the deities that the Yoruba people honored, revered and called upon for guidance. The Orishas are all children of the most high god, Olodumare. The Orishas act as Olodumare's emissaries and handle problems for humans on earth. They rule over the forces of nature and are called upon for healing and blessings.